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What is Paxil ®?
Paxil ® (paroxetine hydrochloride) is an orally administered psychotropic drug. Paxil (paroxetine) is one of a class of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). These drugs increase the activity of an important brain chemical called serotonin, a chemical know to be deficient in patients with MDD (major depressive disorder).
Paxil is approved for use in adults for the following indications: major depressive disorder, obsessive compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder. It was the first antidepressant formally approved in the United States for the treatment of social phobia, causing it to be sometimes referred to (although inaccurately) as an anti-shyness drug.

Paxil Normal Dose
Take Paxil, Seroxat, paroxetine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take Paxil, Seroxat, paroxetine with food or milk if it upsets your stomach. Never take more Paxil, Seroxat, paroxetine than is prescribed for you. If your pain is not being adequately treated, talk to your doctor. Store Paxil, Seroxat, paroxetine at room temperature away from moisture and heat.

Paxil Missed Dose
Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

Paxil Over Dose
Seek emergency medical attention. Symptoms of a Paxil, Seroxat, paroxetine overdose include somnolence, coma, nausea, tremor, tachycardia, confusion, vomiting, and dizziness. Other notable signs and symptoms observed with overdoses involving paroxetine (alone or with othersubstances) include mydriasis, convulsions (status epilepticus), ventriculardysrhythmias, hypertension, aggressive reactions, syncope, hypotension, stupor, bradycardia, dystonia, rhabdomyolysis, symptoms of hepatic dysfunction (hepatic failure, hepatic necrosis, jaundice, hepatitis, and hepatic steatosis), serotoninsyndrome, manic reactions, myoclonus, acute renal failure, and urinary retention.

Paxil Side Effects
Common side effects include: drowsiness, sleepiness , nausea, upset stomach, dry mouth, constipation, diarrhea, rash, itch and changes in urination. Jaw, neck, and back muscle spasms, fever, chills, sore throat, or flu-like symptoms, yellowing of the skin or eyes. Sexual problems is fairly common, but reversible, in both men and women: decrease of sexual desire, delayed orgasm or anorgasmia. You should contact your doctor immediately if any of the above symptoms is severe or persistent.

Paxil Precautions
Use caution when driving, operating machinery, or performing other hazardous activities. If you experience drowsiness or dizziness, avoid these activities. Avoid sleeping pills, antihistamines, sedatives, and tranquilizers except under the supervision of your doctor. These may also make you drowsy. Avoid alcohol or at least ask your doctor about the safe use of alcoholic beverages while you are taking paroxetine.

Talk to your doctor and pharmacist before or if you are taking any prescription drugs or over-the-counter medicines or nutritional supplements. Especially if you are taking any of the followings:
almotriptan (Axert), alprazolam (Xanax), amiodarone (Cordarone, Pacerone), amitriptyline (Elavil), amoxapine (Asendin), atazanavir (Reyataz), benzodiazepine, bromocriptine (Parlodel), bupropion (Wellbutrin), buspirone (Buspar), carbamazepine (Tegretol), celecoxib (Celebrex), chlordiazepoxide (Librium), chlorpromazine (Thorazine), cimetidine (Tagamet, Tagamet HB), citalopram (Celexa), clomipramine (Anafranil), clopidogrel (Plavix), clorazepate (Tranxene), codeine, desipramine (Norpramin), dexamethasone (Decadron), dextromethorphan, diazepam (Valium), dicloxacillin (Dynapen), digoxin (Lanoxin), dipyridamole (Persantine), doxepin (Adapin, Sinequan), encainide (Enkaid), flecainide (Tambocor), fluphenazine (Prolixin), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), frovatriptan (Frova), haloperidol (Haldol), ibuprofen (Advil, Motrin), imipramine (Tofranil), isoniazid (INH, Nydrazid), lithium (Eskalith, Lithobid), meperidine (Demerol), mesoridazine (Serentil), methadone (Dolophine), metoclopromide (Reglan), metoprolol (Lopressor, Toprol XL), mexiletine (Mexitil), moricizine (Ethmozine), naproxen (Aleve, Naprosyn), naratriptan (Amerge), nortriptyline (Aventyl, Pamelor), odansetron (Zofran), perphenazine (Trilafon), phenobarbital (Luminal, phenothiazine, Solfoton), phenytoin (Dilantin), pimozide (Orap), prochlorperazine (Compazine), procyclidine (Kemadrin), propafenone (Rythmol), propoxyphene (Darvon), propranolol (Inderal), protriptyline (Vivactil), quinidine (Quinidex), ranitidine (Zantac), rifampin (Rifadin, Rimactane), risperidone (Risperdal), ritonavir (Norvir), rizatriptan (Maxalt), sertraline (Zoloft), sumatriptan (Imitrex), tamoxifen (Nolvadex), temazepam (Restoril), terbinafine (Lamisil), theophylline/theopylline (Theobid, Theo-Dur, Theolair, Theochron, Elixophyllin, Choledyl, Quibron T, Slo-Bid, Slo-Phyllin), thioridazine, ticlopidine (Ticlid), timolol (Blocadren), tramadol (Ultram), trazodone (Desyrel), triazolam (Halcion), trimipramine (Surmontil), venlafaxine (Effexor), warfarin (Coumadin), zolmitriptan (Zomig), and Saint John's Wort or Tryptophan.

Paxil Drug Interaction
Warnings Potential for Interaction With Monoamine Oxidase Inhibitors: In patients receiving another serotonin reuptake inhibitor drug in combination with a monoamine oxidaseinhibitor (MAOI), there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations ofvital signs, and mental status changes that include extreme agitation progressing to delirium and coma. These reactions have also been reported in patients who have recently discontinued that drug and have been started on an MAOI. Some cases presented with features resembling neuroleptic malignant syndrome. While there are no human data showing such an interaction with PAXIL, limited animal data on the effects of combineduse of paroxetine and MAOIs suggest that these drugs may act synergistically to elevate blood pressure and evoke behavioral excitation. Therefore, it is recommended that PAXIL not be used in combination with an MAOI, or within 14 days of discontinuing treatment with an MAOI. At least 2 weeks should be allowed after stopping PAXIL before starting anMAOI.

Potential Interaction With Thioridazine: Thioridazine administration alone produces prolongation of the QTc interval, which is associated with serious ventricular arrhythmias. Therefore, it is recommended that paroxetine not be used in combination with thioridazine.

Paxil Contraindications
Concomitant use in patients taking either monoamine oxidase inhibitors (MAOIs) orthioridazine is contraindicated. PAXIL is contraindicated in patients with a hypersensitivity to paroxetine or any of the inactive ingredients in PAXIL.

Discontinuation of Treatment with Paxil:
Symptoms associated with discontinuation of Paxil have been reported. Patients should be monitored for these symptoms when discontinuing treatment, regardless of the indication for which Paxil is being prescribed. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered.Subsequently, the physician may continue decreasing the dose but at a more gradual rate.

Paxil Notes
Addiction Potential & Withdrawal Symptoms - The manufacturers claim it is impossible to get addicted. Other campaigners disagree. The medical community generally considers that withdrawal symptoms are not enough to regard a drug as addictive; it has to leave the user needing more and more in order to gain the same desired effect. That's not the case with Paroxetine, as the body does not become tolerant to Parexotine's positive effects. Note, however, that addiction is generally also an extremely debated issue, although no drug is generally considered to be addictive that does not have both withdrawal symptoms and tolerance.

Recent studies have found that the drug is relatively ineffective in children, and that they are prone to becoming suicidal when first given it.

Paxil Manufacturer
GlaxoSmithKline. Paxil ® is a registered trademark of GlaxoSmithKline

Paroxetine Brand Names
Paxil ®, Paxil CR ®, (United States), Seroxat ® (UK, Europe), Aropax ® (Australia), Pexeva ®
Misspellings: Paxilte Pakcil Packsil Paxilh Paxill Paxille paroxetine parotexine paxerotine paxoretine parexotine, parocksetine, paroxeteen paroxetin paroxetene

Source: NIH.gov, wikipedia.org, GlaxoSmithKline, drugs.com

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