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What is Paxil ®?
Paxil ® (paroxetine hydrochloride) is an orally administered psychotropic drug.
Paxil (paroxetine) is one of a class of medicines called Selective Serotonin
Reuptake Inhibitors (SSRIs). These drugs increase the activity of an important
brain chemical called serotonin, a chemical know to be deficient in patients
with MDD (major depressive disorder).
Paxil is approved for use in adults for the following indications: major depressive
disorder, obsessive compulsive disorder, panic disorder, social anxiety disorder,
generalized anxiety disorder, and post-traumatic stress disorder. It was the
first antidepressant formally approved in the United States for the treatment
of social phobia, causing it to be sometimes referred to (although inaccurately)
as an anti-shyness drug.
Paxil Normal Dose
Take Paxil, Seroxat, paroxetine exactly as directed by your doctor. If you do
not understand these directions, ask your pharmacist, nurse, or doctor to explain
them to you. Take each dose with a full glass of water. Take Paxil, Seroxat,
paroxetine with food or milk if it upsets your stomach. Never take more Paxil,
Seroxat, paroxetine than is prescribed for you. If your pain is not being adequately
treated, talk to your doctor. Store Paxil, Seroxat, paroxetine at room temperature
away from moisture and heat.
Paxil Missed Dose
Take the missed dose as soon as you remember. Do not take a double dose of this
medication. Wait the prescribed amount of time before taking your next dose.
Paxil Over Dose
Seek emergency medical attention. Symptoms of a Paxil, Seroxat, paroxetine overdose
include somnolence, coma, nausea, tremor, tachycardia, confusion, vomiting,
and dizziness. Other notable signs and symptoms observed with overdoses involving
paroxetine (alone or with othersubstances) include mydriasis, convulsions (status
epilepticus), ventriculardysrhythmias, hypertension, aggressive reactions, syncope,
hypotension, stupor, bradycardia, dystonia, rhabdomyolysis, symptoms of hepatic
dysfunction (hepatic failure, hepatic necrosis, jaundice, hepatitis, and hepatic
steatosis), serotoninsyndrome, manic reactions, myoclonus, acute renal failure,
and urinary retention.
Paxil Side Effects
Common side effects include: drowsiness, sleepiness , nausea, upset stomach,
dry mouth, constipation, diarrhea, rash, itch and changes in urination. Jaw,
neck, and back muscle spasms, fever, chills, sore throat, or flu-like symptoms,
yellowing of the skin or eyes. Sexual problems is fairly common, but reversible,
in both men and women: decrease of sexual desire, delayed orgasm or anorgasmia.
You should contact your doctor immediately if any of the above symptoms is severe
or persistent.
Paxil Precautions
Use caution when driving, operating machinery, or performing other hazardous
activities. If you experience drowsiness or dizziness, avoid these activities.
Avoid sleeping pills, antihistamines, sedatives, and tranquilizers except under
the supervision of your doctor. These may also make you drowsy. Avoid alcohol
or at least ask your doctor about the safe use of alcoholic beverages while
you are taking paroxetine.
Talk to your doctor and pharmacist before or if you are taking any prescription
drugs or over-the-counter medicines or nutritional supplements. Especially if
you are taking any of the followings:
almotriptan
(Axert), alprazolam
(Xanax), amiodarone
(Cordarone,
Pacerone),
amitriptyline
(Elavil), amoxapine
(Asendin),
atazanavir
(Reyataz),
benzodiazepine,
bromocriptine
(Parlodel),
bupropion
(Wellbutrin),
buspirone
(Buspar), carbamazepine
(Tegretol),
celecoxib
(Celebrex),
chlordiazepoxide
(Librium),
chlorpromazine
(Thorazine),
cimetidine
(Tagamet,
Tagamet HB),
citalopram
(Celexa), clomipramine
(Anafranil),
clopidogrel
(Plavix), clorazepate
(Tranxene),
codeine,
desipramine
(Norpramin),
dexamethasone
(Decadron),
dextromethorphan,
diazepam
(Valium), dicloxacillin
(Dynapen),
digoxin (Lanoxin),
dipyridamole
(Persantine),
doxepin (Adapin, Sinequan),
encainide
(Enkaid), flecainide
(Tambocor),
fluphenazine
(Prolixin),
fluoxetine
(Prozac, Sarafem),
fluvoxamine
(Luvox), frovatriptan
(Frova), haloperidol
(Haldol), ibuprofen
(Advil, Motrin), imipramine
(Tofranil),
isoniazid
(INH, Nydrazid),
lithium (Eskalith,
Lithobid),
meperidine
(Demerol),
mesoridazine
(Serentil),
methadone
(Dolophine),
metoclopromide
(Reglan), metoprolol
(Lopressor,
Toprol XL),
mexiletine
(Mexitil),
moricizine
(Ethmozine),
naproxen
(Aleve, Naprosyn),
naratriptan
(Amerge), nortriptyline
(Aventyl,
Pamelor),
odansetron
(Zofran), perphenazine
(Trilafon),
phenobarbital
(Luminal,
phenothiazine,
Solfoton),
phenytoin
(Dilantin),
pimozide
(Orap),
prochlorperazine
(Compazine),
procyclidine
(Kemadrin),
propafenone
(Rythmol),
propoxyphene
(Darvon), propranolol
(Inderal),
protriptyline
(Vivactil),
quinidine
(Quinidex),
ranitidine
(Zantac), rifampin
(Rifadin,
Rimactane),
risperidone
(Risperdal),
ritonavir
(Norvir), rizatriptan
(Maxalt), sertraline
(Zoloft), sumatriptan
(Imitrex),
tamoxifen
(Nolvadex),
temazepam
(Restoril),
terbinafine
(Lamisil),
theophylline/theopylline
(Theobid,
Theo-Dur,
Theolair,
Theochron,
Elixophyllin,
Choledyl,
Quibron T,
Slo-Bid,
Slo-Phyllin),
thioridazine,
ticlopidine
(Ticlid), timolol (Blocadren),
tramadol
(Ultram), trazodone
(Desyrel),
triazolam
(Halcion),
trimipramine
(Surmontil),
venlafaxine
(Effexor),
warfarin
(Coumadin),
zolmitriptan
(Zomig), and
Saint
John's Wort or Tryptophan.
Paxil Drug Interaction
Warnings Potential for Interaction With Monoamine Oxidase Inhibitors: In patients
receiving another serotonin reuptake inhibitor drug in combination with a monoamine
oxidaseinhibitor (MAOI), there have been reports of serious, sometimes fatal,
reactions including hyperthermia, rigidity, myoclonus, autonomic instability
with possible rapid fluctuations ofvital signs, and mental status changes that
include extreme agitation progressing to delirium and coma. These reactions
have also been reported in patients who have recently discontinued that drug
and have been started on an MAOI. Some cases presented with features resembling
neuroleptic malignant syndrome. While there are no human data showing such an
interaction with PAXIL, limited animal data on the effects of combineduse of
paroxetine and MAOIs suggest that these drugs may act synergistically to elevate
blood pressure and evoke behavioral excitation. Therefore, it is recommended
that PAXIL not be used in combination with an MAOI, or within 14 days of discontinuing
treatment with an MAOI. At least 2 weeks should be allowed after stopping PAXIL
before starting anMAOI.
Potential Interaction With Thioridazine: Thioridazine administration alone produces prolongation of the QTc interval, which is associated with serious ventricular arrhythmias. Therefore, it is recommended that paroxetine not be used in combination with thioridazine.
Paxil Contraindications
Concomitant use in patients taking either monoamine oxidase inhibitors (MAOIs)
orthioridazine is contraindicated. PAXIL is contraindicated in patients with
a hypersensitivity to paroxetine or any of the inactive ingredients in PAXIL.
Discontinuation of Treatment with Paxil:
Symptoms associated with discontinuation of Paxil have been reported. Patients
should be monitored for these symptoms when discontinuing treatment, regardless
of the indication for which Paxil is being prescribed. A gradual reduction in
the dose rather than abrupt cessation is recommended whenever possible. If intolerable
symptoms occur following a decrease in the dose or upon discontinuation of treatment,
then resuming the previously prescribed dose may be considered.Subsequently,
the physician may continue decreasing the dose but at a more gradual rate.
Paxil Notes
Addiction Potential & Withdrawal Symptoms - The manufacturers claim it is
impossible to get addicted. Other campaigners disagree. The medical community
generally considers that withdrawal symptoms are not enough to regard a drug
as addictive; it has to leave the user needing more and more in order to gain
the same desired effect. That's not the case with Paroxetine, as the body does
not become tolerant to Parexotine's positive effects. Note, however, that addiction
is generally also an extremely debated issue, although no drug is generally
considered to be addictive that does not have both withdrawal symptoms and tolerance.
Recent studies have found that the drug is relatively ineffective in children,
and that they are prone to becoming suicidal when first given it.
Paxil Manufacturer
GlaxoSmithKline. Paxil ® is a registered trademark of GlaxoSmithKline
Paroxetine Brand Names
Paxil ®, Paxil CR ®, (United States), Seroxat ® (UK, Europe), Aropax ® (Australia),
Pexeva ®
Misspellings: Paxilte Pakcil Packsil Paxilh Paxill Paxille paroxetine parotexine
paxerotine paxoretine parexotine, parocksetine, paroxeteen paroxetin paroxetene
Source: NIH.gov, wikipedia.org, GlaxoSmithKline, drugs.com
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